Book Luxury Monthly Rentals in Santo Spirito

We selected the 44 homes worth renting in this location

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Home spotlights in Santo Spirito

Terracotta & White Wood

Terracotta & White Wood

  • 6 guests

  • 2 bedrooms

Santo Spirito, Florence

Footsteps from the backstreet trattoria street of Borgo S. Jacopo, this apartment is perfect for a foodie visit to Florence.

Arno View

Arno View

  • 6 guests

  • 3 bedrooms

Santo Spirito, Florence

This apartment in Florence boasts amazing views of the city and the Arno River. Housed in a 14th-century building, this elegant home, furnished with works by renowned local artists, offers a blend of historical charm and modern sophistication.

Golden Halo

Golden Halo

  • 5 guests

  • 2 bedrooms

San Frediano, Florence

This smart apartment puts you right in the centre of Florence. Whether you're planning to tick off your sightseeing list, visiting your favourite artworks, or indulging in the fine Tuscan cuisine, the very best of the city is right on your doorstep.

Ode to Santa Maria

Ode to Santa Maria

  • 4 guests

  • 1 bedrooms

District 1, Florence

Situated in the heart of Florence, with the iconic Ponte Vecchio only a stone’s throw away, this home gives you access to some of the capital’s best sights. See the city’s love of art in renaissance galleries and museums within walking distance, and don’t miss the touristy bits like the Cathedral of Santa Maria del Fiore and Piazzale Michelangelo – more of a walk, but worth the views.


We selected the top 3% holiday homes in Santo Spirito Monthly Rentals

Explore the 44 most perfect homes in our collection

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Most popular homes in Santo Spirito

The Raffaella Rose

The Raffaella Rose

  • 3 guests

  • 1 bedrooms

San Frediano, Florence

Florence Retreat

Florence Retreat

  • 4 guests

  • 1 bedrooms

Santo Spirito, Florence

Alberata Selva

Alberata Selva

  • 6 guests

  • 3 bedrooms

Santo Spirito, Florence

Maggio Romance

Maggio Romance

  • 2 guests

  • 1 bedrooms

Santo Spirito, Florence

From Firenze

From Firenze

  • 4 guests

  • 1 bedrooms

Santo Spirito, Florence

Palazzo Pitti Retreat

Palazzo Pitti Retreat

  • 4 guests

  • 2 bedrooms

Santo Spirito, Florence

Pitti Pad

Pitti Pad

  • 8 guests

  • 4 bedrooms

Santo Spirito, Florence

What a Pitti

What a Pitti

  • 4 guests

  • 2 bedrooms

Santo Spirito, Florence

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Frequently asked questions

Discover the ultimate collection of luxury Monthly Rentals in Santo Spirito, Florence, Tuscany, Italy, and say goodbye to all your travel troubles. Here at Plum Guide, it is our promise that each and every home in our range is in the top 3% of homes in its location, so there is no doubting the consistent quality we are able to offer. Secure your extended or short stay today and enjoy the trip of a lifetime in your fully furnished home, with every property on our site including all linens, essential bathroom toiletries, and a perfectly-equipped kitchen. Our meticulous home critics test everything from Wifi speed to a home's design, so you really can trust our judgement. Rent your perfect Santo Spirito Monthly Apartment today with the help of our team of experts, on standby 24/7 to assist you with absolutely anything.

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